Fig. 4.

Efficacy studies. Evolution of parasitemia in P. vinckei-infected mice during and after i.p. treatments. (A) Four days of treatment (D₁ to D₄) with C₁₂K-2α₈. Symbols: dashed line, vehicle; circle, triangle, and rectangle, doses of 5, 25, and 50 mg/kg, respectively (n = 3 mice/group). Note: 2 of the 50-mg/kg-treated mice died on D₅, and the third was parasite-free on D₂₀. (B) Effect of 2 days' treatment with 50 mg/kg/day of C₁₂K-2α₈ (n = 4 mice/group). Symbols: dashed line, vehicle; circle, OAK treatment (D₁ and D₂). All mice died with high parasitemia. (C) Effect of 3 days' treatment with 50 mg/kg/day of C₁₂K-2α₈ (n = 4 mice/group). Symbols: dashed line, vehicle; circle, OAK treatment (D₁ to D₃). Note: three treated mice died on D₅, D₉, and D₁₁, and the fourth was parasite free on D₂₀. (D) Four days of treatment (D₁ to D₄) with OAK analogs using 50 mg/kg/day (n = 4). Symbols: dashed line, vehicle; circle, treatment with C₈K-2α₈; rectangle, treatment with C₁₂K-1α₈. All results are expressed as means ± SEM.