Table 3.
Six-year trends in linezolid resistance rates observed in the LEADER Program (2004 to 2009; 33,378 isolates)
| Organism (no. tested) | % of isolates nonsusceptible or resistant to linezolida |
|||||
|---|---|---|---|---|---|---|
| 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | |
| S. aureus (18,537) | 0.00 | 0.03 | 0.03 | 0.06 | 0.10 | 0.15 |
| CoNS (4,526) | 0.20 | 1.13 | 1.61 | 1.76 | 1.64 | 1.47 |
| Enterococci (4,577) | 0.80 | 0.64 | 1.83 | 1.13 | 0.55 | 0.49 |
| S. pneumoniae (3,292) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| viridans group streptococci (925) | NT | NT | 0.00 | 0.00 | 0.00 | 0.00 |
| Beta-hemolytic streptococci (1,521) | NT | NT | 0.00 | 0.00 | 0.00 | 0.00 |
| All organisms (33,378) | 0.14 | 0.24 | 0.45 | 0.44 | 0.36 | 0.34 |
a
CLSI interpretation criteria from M100-S20-U (2010). NT, not tested.