Table 4.
Staphylococcus species resistant to linezolid (MIC, ≥8 μg/ml) in the 2009 LEADER Program
| Isolate | Organism | City and state | Age (yr)/sexa | Linezolid MIC (μg/ml)b | Resistance mechanism(s) |
|---|---|---|---|---|---|
| 004-272C | S. aureus | Akron, OH | 52/M | 16 | cfr |
| 444-2031L | S. aureus | Palo Alto, CA | 14/F | 16 | G2576T |
| 424-2265L | S. aureus | Hartford, CT | 68/M | 8 | L3 (S145 deletion) |
| 027-1687A | S. aureus | Louisville, KY | 53/M | 16 | cfr |
| 427-99L | S. aureus | Wichita, KS | 17/M | 16 | G2576T |
| 004-3417A | S. epidermidis | Akron, OH | 89/M | 128 | G2576T |
| 412-2466L | S. epidermidis | Memphis, TN | 71/M | 8 | L3 (V154L, L101V, A157R), L4 (P171S) |
| 426-2174L | S. epidermidis | Tempe, AZ | 55/M | 128 | cfr |
| 426-2179L | S. epidermidis | Tempe, AZ | 73/F | 32 | G2576T |
| 107-7715A | S. epidermidis | Lexington, KY | 40/M | 16 | L3 (A157R, L101V, V154L), L4 (N158S) |
| 443-2409L | S. epidermidis | St. Paul, MN | 84/M | 32 | G2576T |
| 003-4596A | S. epidermidis | Detroit, MI | 64/F | 16 | L3 (H146Q), L4 (N158S) |
| 003-4593A | S. capitis | Detroit, MI | 74/F | 8 | cfr |
| 441-1590L | S. epidermidis | Boston, MA | 59/M | 16 | L3 (H146Q), L4 (N158S) |
| 129-25A | S. epidermidis | New Brunswick, NJ | 71/M | 128 | G2576T |
| 051-2286A | S. epidermidis | Salt Lake City, UT | 55/F | 128 | G2576T |
| 116-13800A | S. epidermidis | Houston, TX | 24/M | 128 | G2576T |
a
M, male; F, female.
b
MIC from a reference frozen-form panel with a linezolid MIC range to 128 μg/ml.