Table 1.

Chloroquine pharmacokinetic data from healthy mammalian species

Matrix and species	n	Wt (kg)	Half-life (h)	CLa (liters/h/kg)	Va (liters/kg)	Reference
Plasma
Mice		0.03	46.6	9.9	667	—f
Ratsb		0.25	10.8	10.4	163	55
Rabbitsc	5	1.25	26.7	5.9	226	50
Monkeysc	6	4.5	18.8	2.34	63	57
Human, adults	11	75	282	0.58	204	27
Human, adults	5	72	1,392	0.88	710	22
Human, adults	7	58	217	0.68	181	3
Human, adults	6	54	250	0.74	261	69
Human, adults	8	58	192	0.55	154	69
Human, adults	10	54	268	0.66	132	19
Human, adults	5	64	386	0.44	250	71
Human, adults	4	76	374	0.58	302	71
Human, adults	5	73	479	0.57	283	71
Human, adults	6	45	67	0.83	82.6	17
Human, adults	5	58	70.5	0.62	63.5	17
Human, adults	30	52	291	0.46	129.5	32
Total no. of human adultsd	102
Mean ± SEM		62 ± 3	304 ± 31	0.63 ± 0.04	211 ± 22
Whole blood
Micee		0.025		16.5	13.1	11
Rabbits	8	2.0	223	0.31	86	2
Dogs, beagle	7	11.8	302	0.13	53	1
Human, adults	5	72	1,248	0.091	81	22
Human, adults	7	59	150	0.21	45.3	47
Human, adults	17	66.5	162	0.25	57.8	59

^aCL is apparent clearance (CL/F), and V is apparent volume of distribution (V/F).

^bPharmacokinetic parameters determined from concentration-time profile of 48 h after dose.

^cPharmacokinetic parameters determined from concentration-time profile of 24 h after dose.

^dPharmacokinetic data from 12 human studies comprising 102 volunteers.

^ePharmacokinetic parameters determined from concentration-time profile of 4 h after dose.

^f—, present study.