Table 2.
Chloroquine pharmacokinetic data from mammalian species with malaria infection
| Matrix and species | n | Wt (kg) | Half-life (h) | CLa (liters/h/kg) | Va (liters/kg) | Reference |
|---|---|---|---|---|---|---|
| Plasma | ||||||
| Mice | 0.03 | 99.3 | 7.9 | 1,122 | —d | |
| Monkeysb | 6 | 4.5 | 30.6 | 1.02 | 44 | 57 |
| Human, adults | 11 | 53 | 302 | 0.61 | 136 | 19 |
| Human, adults | 6 | 46 | 116 | 0.595 | 99.7 | 17 |
| Human, adults | 5 | 56 | 76 | 0.53 | 58.2 | 17 |
| Whole blood | ||||||
| Micec | 0.025 | 5.1 | 16.8 | 11 | ||
| Human, children | 9 | 21 | 0.15 | 112 | 52 | |
| Human, children | 83 | 12 | 115 | 0.24 | 262 | 51 |
| Human, adults | 7 | 54 | 201 | 0.099 | 28.6 | 47 |
| Human, adults | 15 | 46 | 209 | 0.189 | 57.3 | 37 |
a
CL is apparent clearance (CL/F), and V is apparent volume of distribution (V/F).
b
Pharmacokinetic parameters determined from concentration-time profile of 24 h after dose.
c
Pharmacokinetic parameters determined from concentration-time profile of 4 h after dose.
d
—, present study.