Table 3.

Bactericidal activities of compounds alone and in combination with spectinomycin

Compound	Result for M. tuberculosis H37Rv witha:
	Compound aloneb			Compound in combination with spectinomycinc
	MIC	MBC	MBC/MIC	MICsyn	MBCsyn	MBC/MIC
Spectinomycin	80	320–640	4–8	NA	NA
Bromperidol	64	64	1	5	5–10	1–2
Clarithromycin	32–64	>128	≥4–8	10–20	320	16–32
Isoniazid	0.03	0.03	1	80	320–640	4–8
Ketoconazole	16–32	64–128	4	5–10	160	16–32
Rifampin	0.06	0.25–0.5	4–8	10–20	160	8–16

^aMIC was determined after 8 days of incubation in the presence of the compound(s). To calculate the MBC, 5 μl was transferred to 200 μl of drug-free medium and incubated for 8 additional days. NA, not applicable.

^bMIC and MBC (mg/liter) for every compound tested individually.

^cSpectinomycin synergistic MIC (MIC_syn) and synergistic MBC (MBC_syn) (mg/liter) in the presence of a 1/4×MIC of the compound, as follows: bromperidol, 16 mg/liter; clarithromycin, 16 mg/liter; isoniazid, 0.007 mg/liter; ketoconazole, 8 mg/liter; and rifampin, 0.015 mg/liter.