Table 5.
Bromperidol enhancement of pairwise synergistic combinations against M. tuberculosis
| Drug(s)b | MIC (mg/liter) for M. tuberculosis H37Rv ofa: |
|||||
|---|---|---|---|---|---|---|
| Spectinomycin | Rifampin | Bromperidol | ||||
| Drug alone | 80 | 0.025 | 64–128 | |||
| SPT + RIF | 10–20 | (4–8) | 0.06 | (4) | NA | |
| SPT + BPDL | 5 | (16) | NA | 8 | (8–16) | |
| RIF + BPDL | NA | 0.06 | (4) | 16 | (4–8) | |
| SPT + RIF + BPDL | 0.6 | (128) | 0.015–0.03 | (8–16) | 16b | (4–8) |
a
MICs of the antibiotics alone or within different combinations. When in combination, values represent the lowest MIC for each antibiotic. Values in parentheses indicate fold reduction in the MIC compared to that of the antibiotic alone. Bromperidol was included in the combination at a fixed concentration of 16 mg/liter (4- to 8-fold below the MIC). NA, not applicable.
b
BPDL, bromperidol; RIF, rifampin; SPT, spectinomycin.