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Staphylococcal peptidoglycan-synthetic pathway and proposed mode of action of tripropeptin C. We assume that tripropeptin C (TPPC) forms a tertiary complex with undecaprenyl pyrophosphate (C55-PP) and calcium ions (molar ratio, 1:1:1). Interaction between TPPC and C55-PP leads to disruption of the lipid cycle and results in inhibition of peptidoglycan synthesis.
