Table 1.

MICs of MX-2401, vancomycin, and oxacillin against isolates of Gram-positive bacteria

Organism	Drug (no. of isolates tested)	MIC (μg/ml)
		Range	50%	90%
S. aureusa	MX-2401 (15)	0.25–4	0.5	2
	Vancomycin (15)	≤0.125–4	0.25	2
	Oxacillin (10)	≤0.125–>64	>64	>64
Coagulase-negative	MX-2401 (13)	0.25–4	1	2
staphylococcib	Vancomycin (13)	≤0.125–4	2	2
	Oxacillin (10)	≤0.125–>64	32	64
Enterococcus spp.c	MX-2401 (18)	0.25–4	2	4
	Vancomycin (18)	0.25–>64	>64	>64
	Oxacillin (11)	32–>64	>64	>64
Streptococcus spp.d	MX-2401 (12)	≤0.125–2	0.25	2
	Vancomycin (12)	≤0.125–2	0.25	1
	Oxacillin (10)	≤0.125–32	0.5	16
Anaerobese	MX-2401 (6)	0.5–1	NAf	NA
	Vancomycin (6)	0.25–1	NA	NA
	Oxacillin (6)	0.125–4	NA	NA

^aIncludes methicillin-sensitive and -resistant, vancomycin-intermediate, tetracycline-resistant, and mupirocin-resistant S. aureus.

^bIncludes methicillin-sensitive and -resistant coagulase-negative staphylococci (including 11 strains of S. epidermidis).

^cIncludes vancomycin-sensitive and -resistant (VanA-, VanB-, and VanC-positive strains), linezolid-sensitive, -intermediate, and -resistant, quinupristin-dalfopristin-sensitive, -intermediate, and resistant, and tetracycline-resistant Enterococcus spp. (E. faecalis, E. faecium, and E. gallinarum).

^dIncludes penicillin-sensitive, -intermediate, and -resistant and erythromycin-sensitive and -resistant S. pneumoniae and azithromycin-resistant viridans group streptococci.

^eIncludes Peptostreptococcus magnus, Clostridium difficile, and erythromycin-resistant and -sensitive Propionibacterium acnes.

^fNA, not available.