Table 5.

Levels of 5′-phosphorylated 3′-azido-ddA in MT-2 cells after 4 h of incubation with 3′-azido-ddA at 5, 12.5, 25, or 50 μM

3′-azido-ddA concn (μM)	Level of metabolized 3′-azido-ddA (pmol/106 cells)a		Level of metabolized 3′-azido-ddA (μM)d
	TPb	DPc	TP	DP
5	0.13 ± 0.02	0.030 ± 0.002	0.240 ± 0.004	0.054 ± 0.003
12.5	0.22 ± 0.01	0.08 ± 0.01	0.40 ± 0.02	0.15 ± 0.02
25	0.36 ± 0.05	0.17 ± 0.04	0.66 ± 0.09	0.30 ± 0.07
50	0.77 ± 0.07	0.25 ± 0.07	1.41 ± 0.14	0.45 ± 0.13

^aMeans ± standard deviations of three experiments.

^bTP is 3′-azido-ddA-5′-triphosphate.

^cDP is 3′-azido-ddA-5′-diphosphate.

^dMeans ± standard deviations of three experiments, determined using an average diameter for MT-2 cells of 12.3 μm.