Table 1.
Changes in the sizes of the lesions of murine chromoblastomycosis by F. pedrosoi and percentage of positive cultures after 16 weeks of therapy
| Drug and dose (mg/kg of body wt) | % Change in lesion sizea | % of positive cultures |
|---|---|---|
| Control | 92.0 (368.3) | 100 |
| ITZ | ||
| 25 | 14.7 (220.9) | 100 |
| 50 | −20.0 (89.9) **b | 75 |
| PSC | ||
| 10 | −30.4 (107.6) | 75 |
| 20 | −75.0 (31.4) ** | 50** |
| TRB | ||
| 150 | 19.3 (163.3) | 100 |
| 250 | −0.6 (110.3) ** | 100 |
| VRC | ||
| 10 | 90.8 (67.3) | 100 |
| 20 | 35.9 (138.3) | 100 |
a
Lesions changes are expressed as median values (interquartile range).
b
**, Mann-Whitney test P value of <0.05 in comparison with the control group.