Table 5.
Summary of sensitivities, specificities, positive predictive values, and negative predictive values of the combined-disk tests using different boronic acid compounds and different antibiotic substrates in the phenotypic detection of KPC-producing isolates
| Antibiotic substrate and boronic acid | Sensitivity (%) | Specificity (%) | PPVa (%) | NPVb (%) |
|---|---|---|---|---|
| Imipenem | ||||
| APBA, 300 μg | 64.3 | 97.6 | 96.0 | 75.6 |
| APBA, 600 μg | 82.1 | 97.6 | 96.8 | 86.1 |
| PBA, 400 μg | 100 | 97.6 | 97.4 | 100 |
| Meropenem | ||||
| APBA, 300 μg | 77.7 | 97.6 | 96.7 | 83.2 |
| APBA, 600 μg | 96.4 | 97.6 | 97.3 | 96.9 |
| PBA, 400 μg | 100 | 97.6 | 97.4 | 100 |
a
PPV, positive predictive value.
b
NPV, negative predictive value.