Table 2.
Clonality of antimicrobial-resistant pneumococci isolated in 2006 and 2007, a high-PCV7-uptake eraa
| Serotype-PFGE cluster | No. (%) of isolates | MLST | PMEN clone | No. of drug-resistant carriers who received PCV7b |
P value | |
|---|---|---|---|---|---|---|
| 0 doses (n=86) | 1-4 doses (n=152) | |||||
| PCV7 serotypes | ||||||
| 6B-1 | 1 (0.4) | 5217 | 1 | 0 | 0.183 | |
| 6B-2 | 1 (0.4) | 315 | Poland6BST315 | 0 | 1 | 0.451 |
| 6B-3 | 1 (0.4) | 469 | 1 | 0 | 0.183 | |
| 14-4 | 28 (11.1) | 557 (SLV), 5219 (DLV), 4585 (SLV) | Spain9VST156 | 8 | 16 | 0.763 |
| 14-5 | 3 (1.2) | 9 | England14ST9 | 3 | 0 | 0.020 |
| 14-ND | 1 (0.4) | 4584 | 0 | 1 | 0.451 | |
| 19F-6 | 17 (6.7) | 179 (SLV) | Portugal19FST177 | 8 | 9 | 0.330 |
| 19F-7 | 2 (0.8) | 88 | 1 | 0 | 0.183 | |
| 19F-8 | 2 (0.8) | 5218 | 1 | 1 | 0.682 | |
| 23F-9 | 15 (6.0) | 338 | Colombia23FST338 | 13 | 2 | <0.001 |
| 23F-10 | 6 (2.4) | 338 | Colombia23FST338 | 3 | 1 | 0.102 |
| 23F-11 | 1 (0.4) | 81 | Spain23FST81 | 1 | 0 | 0.183 |
| Non-PCV7 serotypes | ||||||
| 3-12 | 1 (0.4) | 180 | Netherlands3ST180 | 1 | 0 | 0.183 |
| 6A-13 | 5 (2.0) | 490 | 2 | 3 | 0.856 | |
| 6A-14 | 1 (0.4) | 395 | 0 | 1 | 0.451 | |
| 6C-15 | 3 (1.2) | 2689 | 1 | 1 | 0.682 | |
| 6C-16 | 2 (0.8) | 2185 | 1 | 1 | 0.682 | |
| 6C-17 | 11 (4.4) | 3396 | 6 | 5 | 0.193 | |
| 6C-18 | 6 (2.4) | 3396 | 1 | 5 | 0.315 | |
| 6C-19 | 4 (1.6) | 3673 | 2 | 2 | 0.560 | |
| 11A-20 | 12 (4.8) | 4582 | 5 | 6 | 0.510 | |
| 15A-21 | 33 (13.1) | 2105 (SLV), 63 | Sweden15AST63 | 7 | 24 | 0.092 |
| 19A-22 | 24 (9.5) | 276 (SLV), 4267 (SLV) | Denmark14ST230 | 5 | 19 | 0.099 |
| 19A-23 | 11 (4.4) | 416 (DLV) | Netherlands15BST199 | 3 | 8 | 0.531 |
| 19A-24 | 7 (2.8) | 4302, 5221 | 2 | 5 | 0.672 | |
| 19A-21 | 19 (7.5) | 63 | Sweden15AST63 | 2 | 15 | 0.029 |
| 22F-25 | 1 (0.4) | 433 | 1 | 0 | 0.183 | |
| 24F-26 | 7 (2.8) | 230, 1708 (SLV) | Denmark14ST230 | 0 | 7 | 0.043 |
| 33F-27 | 7 (2.8) | 717 | 0 | 7 | 0.043 | |
| NT-28 | 9 (3.6) | 344, 4586 (SLV) | NorwayNTST344 | 3 | 6 | 0.858 |
| NT-29 | 2 (0.8) | 344 | NorwayNTST344 | 1 | 1 | 0.682 |
| NT-30 | 1 (0.4) | 344 | NorwayNTST344 | 0 | 1 | 0.451 |
| NT-31 | 1 (0.4) | 344 | NorwayNTST344 | 0 | 1 | 0.451 |
| NT-32 | 1 (0.4) | 4583 | 1 | 0 | 0.183 | |
| NT-33 | 2 (0.8) | 1156 | 2 | 0 | 0.059 | |
| NT-34 | 1 (0.4) | 5220 (SLV) | NorwayNTST344 | 0 | 0 | |
| NT-35 | 1 (0.4) | 344 | NorwayNTST344 | 0 | 1 | 0.451 |
| NT-36 | 2 (0.8) | 344 | NorwayNTST344 | 0 | 2 | 0.285 |
a
ND, not determined; DLV, double-locus variant of prototype strain of PMEN clone. Boldface data indicate statistically significant differences.
b
For 14 carriers, information on PCV7 was not available.