Table 3.
Clonal diversity of antimicrobial-resistant pneumococci
| Serotype | Pre-PCV7 era (1996 to 2001, n=805) |
Low-PCV7 uptake (2002 and 2003, n=374) |
High-PCV7 uptake (2006 and 2007, n=252) |
|||
|---|---|---|---|---|---|---|
| No. of clones defined by PFGE | SID (95% CIb) | No. of clones defined by PFGE | SID (95% CI) | No. of clones defined by PFGE | SID (95% CI) | |
| Alla | 74 | 0.924 (0.917-0.931) | 48 | 0.936 (0.925-0.947) | 36 | 0.919 (0.910-0.936) |
| PCV7 | 49 | 0.894 (0.884-0.903) | 23 | 0.882 (0.860-0.904) | 11c | 0.782 (0.727-0.837) |
| Non-PCV7 | 34 | 0.916 (0.896-0.937) | 29 | 0.919 (0.898-0.940) | 25 | 0.873 (0.838-0.907) |
| 19A | 9 | 0.644 (0.493-0.794) | 6 | 0.641 (0.528-0.754) | 4 | 0.714 (0.663-0.765) |
| 15A | 2 | 0.173 (−0.027-0.374) | 2 | 0.500 (0.067-0.933) | 1 | 0.00 (0.00-0.00) |
| 6C | 2 | 0.200 (0.104-0.504) | 1 | 0.00 (0.00-0.00) | 5 | 0.754 (0.649-0.859) |
| 6A | 7 | 0.818 (0.727-0.909) | 5 | 0.857 (0.704-1.010) | 2 | 0.330 (−0.072-0.739) |
| 14 | 6 | 0.538 (0.495-0.581) | 7 | 0.616 (0.510-0.720) | 2 | 0.181 (0.094-0.352) |
| 19F | 15 | 0.743 (0.664-0.822) | 7 | 0.711 (0.634-0.789) | 3 | 0.343 (0.980-0.588) |
| 23F | 8 | 0.501 (0.440-0.562) | 3 | 0.093 (−0.006-0.193) | 3 | 0.480 (0.301-0.660) |
| Nontypeable | 3 | 0.351 (0.185-0.517) | 5 | 0.699 (0.583-0.814) | 9 | 0.795 (0.628-0.961) |
a
In the pre-PVC7 era there were nine PFGE clones that contained both PCV7 serotypes and non-PCV7 serotypes; in the low-PVC7-uptake era, there were four PFGE clones that contained both PCV7 serotypes and non-PCV7 serotypes.
b
95% CI, 95% confidence interval.
c
Boldface data indicate statistically significantly differences.