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. 2011 Aug;31(16):3208–3222. doi: 10.1128/MCB.05337-11

Fig. 11.

Fig. 11.

Model for E2-ERα-SP1-C/EBPβ formation and binding to the hPIII promoter of the human prolactin receptor gene. Schematic presentation of the functional domain of ERα, SP1, and C/EBPβ and the cognate DNA binding site of SP1 and C/EBPβ in the hPIII promoter (bp −391 to −351). Each protein is constitutively present as a homodimer. Arrows indicate the interaction at the specific domain between the proteins. ERα, AF transactivation function domain; DBD, DNA binding domain; H, hinge region; LBD, ligand binding domain; SP1 TAD, transactivation domain; ZF, zinc finger motif; C/EBPβ BR, basic region; LZ, leucine zipper domain.