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. 2011 Aug;31(16):3457–3471. doi: 10.1128/MCB.05523-11

Fig. 6.

Fig. 6.

Modulation of Cdc25A expression impacts the survival of mice with implanted breast cancer cells. (A) Cdc25A overexpression leads to breast cancer cell invasion and metastasis into multiple mouse organs. In the mice injected with Cdc25A-OE cells, approximately 20% (4 of 20) had eye metastasis and 30% (6 of 20) had tumor nodules in their livers. In addition, almost all mice had aggressive lymph and lung metastasis. In contrast, no tumor nodules in the eyes or livers were observed and there was a marked reduction in lymph and lung metastasis for the control and Cdc25A-KD breast cancer cells. (B) Kaplan-Meier survival curves of the mice implanted with breast cancer cells with modulation of Cdc25A expression. The horizontal line indicates the time after the mice were injected with the cells via the tail vein. WT, parent MAD-MB-231 breast cancer cells; CK, breast cancer cells with the empty vector; Cdc25A-OE, breast cancer cells with Cdc25 overexpression; Cdc25A-KD, breast cancer cells with Cdc25 knockdown. The number of tested mice was 15 for each group.