Table 1.
Metastatic phenotypes of breast cancer cells are independent of cell growth
| Parameter | Valuea |
||||
|---|---|---|---|---|---|
| Cdc25A-OE | CK | Cdc25A-KD | CK | Cdc25A-KD | |
| Tested time (mo) | 9 | 9 | 9 | 15 | 23 |
| Tumor size (mm3)b | 1,471 | 810 | 390 | 1,459 | 1,467 |
| No. of mice with LN-invasive tumors/total | 10/10 | 5/10 | 2/10 | 6/10 | 2/10 |
| No. of mice with lung-invasive tumors/total | 10/10 | 6/10 | 2/10 | 6/10 | 3/10 |
| No. of tumor nodules per lung | 32 | 12 | 3 | 13 | 4 |
a
CK, MDA-MB-231 breast cancer cells with the empty vector control; Cdc25A-OE, MDA-MB-231 breast cancer cells with Cdc25A overexpression; Cdc25A-KD, MDA-MB-231 breast cancer cells with Cdc25A knockdown.
b
Mean ± SD (n=10).