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Farnesylation is required for the inhibitory effects of progerin on Ran, TPR, SUMO2/3, and H3K9me3. Progeria fibroblasts (HGPS 3199) were treated with FTI-277 (3 μM) or DMSO (0.1%) for 72 h and examined by IF microscopy for the indicated proteins. Scale bar, 20 μm.
