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. 2011 Aug;31(16):3378–3395. doi: 10.1128/MCB.05087-11

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Fig. 3. — Progerin inhibits TPR import. (A) Distribution of endogenous TPR in control (Normal 8469) and progeria (HGPS 1972, HGPS 1498, and HGPS 3199) fibroblasts. (B) HA-lamin A and HA-progerin transfection in HeLa cells costained for endogenous TPR (red) and HA (green). (C) Cotransfection of progerin and a reporter protein that contains the NLS from TPR (pyruvate kinase) (PK-NLS^TPR) followed by localization of endogenous TPR (red) and the PK reporter (green). (D) siRNA-mediated knockdown of NTF2 in HeLa cells and localization of endogenous Ran (green) and TPR (red). (E) siRNA-mediated knockdown of TPR in HeLa cells with localization of endogenous Ran (green) and TPR (red). Scale bars, 20 μm.