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. 2011 Aug;31(16):3378–3395. doi: 10.1128/MCB.05087-11

Fig. 4.

Fig. 4.

SUMO2/3 levels in the nucleus are reduced in response to progerin expression. (A) Overlay of SUMO1 and SUMO2/3 distributions (red) with HA-progerin and HA-WT lamin A (green) in HeLa cells. (B) SUMO2/3 (red) and Ran (green) levels in control (Normal 8469) and progeria (HGPS 1972, HGPS 1498, and HGPS 3199) fibroblasts. (C) Histograms (bin size = 1) of nuclear SUMO2/3 levels from healthy (Normal 8469) (black bars; n = 54) and HGPS patient (HGPS 1972, HGPS 1498, and HGPS 3199) (red lines; n = 56, 65, and 101, respectively) cells. (D) Ran N/C ratio values plotted as a function of nuclear SUMO2/3 levels (ρ values of 0.19 for Normal 8469, 0.82 for HGPS 1972, 0.70 for HGPS 1498, and 0.53 for HGPS 3199). Scale bars, 20 μm.