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Forcing nuclear localization of Ubc9 rescues the Ran gradient in progerin-expressing cells. HeLa cells were cotransfected with HA-WT lamin A and HA-progerin, together with the transport signal fusions of Ubc9. Histograms show the nuclear levels of SUMO2 (bin size = 0.5) and Ran N/C levels (bin size = 0.25) in HA-positive cells expressing ectopic forms of Ubc9.
