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Model of the subfunctionalization of ScSir2 and ScHst1. (A) The conserved domains of ScSir2 and ScHst1 are shown with identity (similarity) percentages. ScHst1 is numbered using previously annotated M29 (Saccharomyces Genome Database [http://www.yeastgenome.org/]) as the start codon, based on observations that expression is unaffected by the mutagenesis of M1 and M6 but eliminated by the mutagenesis of M29 and M31. (B) A proposed model of the subfunctionalization of Sir2.
