Table 2.
Novel variants of HPV 16 E6 and L1 and the LCR according to nucleotide position, variant, altered amino acid, and mutation
| Gene/region | Nt position | Nt |
Amino acid |
Codon no. | Type of mutationa | No. of mutations | ||
|---|---|---|---|---|---|---|---|---|
| Prototype | Variant | Original | Altered | |||||
| E6 | 341 | T | G | Cysteine | Glycine | 80 | M, Tv | 1 |
| L1 | 5569 | G | A | Valine | Valine | 3 | S, Ts | 1 |
| 5596 | A | T | Threonine | Threonine | 12 | S, Tv | 1 | |
| 5836 | A | G | Serine | Serine | 92 | S, Ts | 1 | |
| 5883 | A | C | Lysine | Threonine | 108 | M, Tv | 1 | |
| 5902 | C | A | Threonine | Threonine | 114 | S, Tv | 1 | |
| 6085 | G | A | Methionine | Isoleucine | 175 | M, Ts | 1 | |
| 6164 | A | G | Threonine | Alanine | 202 | M, Ts | 1 | |
| 6166 | C | A | Threonine | Threonine | 202 | S, Tv | 1 | |
| 6427 | G | A | Arginine | Arginine | 289 | S, Ts | 1 | |
| 6505 | A | G | Serine | Serine | 315 | S, Ts | 2 | |
| 6658 | A | T | Threonine | Threonine | 366 | S, Tv | 3 | |
| 6667 | A | T | Serine | Serine | 369 | S, Tv | 9 | |
| 6938 | C | G | Proline | Alanine | 460 | M, Tv | 1 | |
| 7142 | A | C | Lysine | Glutamine | 528 | M, Tv | 1 | |
| LCR | 7168 | A | G | Ts | 17 | |||
| 7174 | A | C | Tv | 9 | ||||
| 7233 | A | G | Ts | 1 | ||||
| 7419 | A | G | Ts | 2 | ||||
| 7429 | G | A | Ts | 1 | ||||
| 7660 | A | G | Ts | 2 | ||||
| 7667 | A | C | Tv | 1 | ||||
| 7700 | T | G | Tv | 1 | ||||
| 7781 | T | A | Tv | 1 | ||||
| 7855 | G | A | Ts | 1 | ||||
| 7859 | A | C | Tv | 1 | ||||
| 16 | G | A | Ts | 1 | ||||
| 48 | G | A | Ts | 2 | ||||
a
M, missense; S, silence; Ts, transition; Tv, transversion.