Table 2.
In vitro susceptibilities of available TRANSNET Candida isolates
| Species (no. of isolates) | Antifungal agent | MIC (μg/ml) |
% Resistanta | ||
|---|---|---|---|---|---|
| Range | MIC50 | MIC90 | |||
| All (383) | Fluconazole | 0.125–64 | 1 | 64 | 16 |
| Voriconazole | 0.015–8 | 0.03 | 1 | 3 | |
| Itraconazole | 0.015–8 | 0.125 | 1 | 17 | |
| Posaconazole | 0.015–16 | 0.125 | 2 | ||
| Caspofungin | 0.012–2 | 0.094 | 0.38 | ||
| Amphotericin B | 0.038–6 | 0.38 | 2 | ||
| C. albicans (154) | Fluconazole | 0.125–64 | 0.25 | 1 | 1 |
| Voriconazole | 0.015–8 | 0.015 | 0.06 | 1 | |
| Itraconazole | 0.015–8 | 0.03 | 0.125 | 2 | |
| Posaconazole | 0.016–16 | 0.047 | 0.125 | ||
| Caspofungin | 0.012–0.25 | 0.047 | 0.125 | ||
| Amphotericin B | 0.038–1.0 | 0.25 | 0.38 | ||
| C. glabrata (119) | Fluconazole | 0.25–64 | 8 | 64 | 23 |
| Voriconazole | 0.015–4 | 0.5 | 2 | 8 | |
| Itraconazole | 0.125–8 | 1 | 16 | 52 | |
| Posaconazole | 0.125–4 | 1 | 2 | ||
| Caspofungin | 0.012–0.38 | 0.125 | 0.19 | ||
| Amphotericin B | 0.094–4 | 0.75 | 1 | ||
| C. parapsilosis (48) | Fluconazole | 0.25–8 | 0.5 | 2 | 0 |
| Voriconazole | 0.015–0.5 | 0.015 | 0.06 | 0 | |
| Itraconazole | 0.015–0.5 | 0.06 | 0.125 | 0 | |
| Posaconazole | 0.012–0.75 | 0.047 | 0.125 | ||
| Caspofungin | 0.064–1 | 0.38 | 0.5 | ||
| Amphotericin B | 0.038–2 | 0.5 | 1.5 | ||
| C. krusei (32) | Fluconazole | 0.25–64 | 32 | 64 | 100 |
| Voriconazole | 0.015–1 | 0.25 | 0.5 | 0 | |
| Itraconazole | 0.015–0.5 | 0.25 | 0.5 | 0 | |
| Posaconazole | 0.032–2 | 0.75 | 1.5 | ||
| Caspofungin | 0.047–2 | 0.38 | 0.5 | ||
| Amphotericin B | 0.25–6 | 2 | 4 | ||
| C. tropicalis (21) | Fluconazole | 0.25–64 | 1 | 8 | 5 |
| Voriconazole | 0.015–8 | 0.125 | 0.5 | 5 | |
| Itraconazole | 0.015–8 | 0.125 | 0.25 | 5 | |
| Posaconazole | 0.023–16 | 0.125 | 0.75 | ||
| Caspofungin | 0.032–1 | 0.064 | 0.19 | ||
| Amphotericin B | 0.19–1.5 | 0.75 | 1 | ||
a
Values assume intrinsic resistance of C. krusei regardless of MIC.