Table 2.
Histopathology results after inoculation of ferrets with H1N1 isolates
| Organ | Severity of lesions by virus and day p.i. (clinical symptom)a |
|||||||
|---|---|---|---|---|---|---|---|---|
| A/California/4/09 |
A/New Caledonia/20/99 |
A/Swine/Iowa/15/30 |
A/Mallard/MN/A108-2355/08b |
|||||
| 3 dpi | 7 dpi | 3 dpi | 7 dpi | 3 dpi | 7 dpi | 3 dpi | 7 dpi | |
| Brain | − | − | − | − | − | − | − | − |
| Trachea | − | − | − | − | − | − | − | − |
| Nasal turbinates | + (rhinitis) | ++ (rhinitis) | + (rhinitis) | ++ (rhinitis) | ++ (rhinitis) | ++ (rhinitis) | − | + (rhinitis) |
| Lung | − | ++ (bronchopneumonia) | + (bronchopneumonia) | − | + (bronchopneumonia) | ++ (bronchopneumonia) | + (bronchopneumonia) | + (bronchopneumonia) |
| Heart | − | − | − | − | − | − | − | − |
| Thymus | − | − | − | − | − | − | − | − |
| Stomach | − | NS | NS | − | − | − | − | − |
| Small intestine | − | − | − | − | − | − | −* | −* |
| Large intestine | − | − | − | − | − | − | − | − |
| Mesenteric lymph node | − | − | − | − | − | − | − | − |
| Pancreas | − | − | − | − | − | − | − | − |
| Liver | + (portal hepatitis) | + (portal hepatitis) | + (portal hepatitis) | + (portal hepatitis) | + (portal hepatitis) | + (portal hepatitis) | + (portal hepatitis) | + (portal hepatitis) |
| Spleen | + (lymphoid hyperplasia) | + (lymphoid hyperplasia) | + (lymphoid hyperplasia) | + (lymphoid hyperplasia) | + (lymphoid hyperplasia) | + (lymphoid hyperplasia) | − | − |
| Kidney | − | − | − | − | − | − | − | − |
| Adrenal gland | − | − | − | NS | − | − | NS | − |
| Bladder | − | − | − | − | − | − | − | − |
a
−, minimal; +, mild; ++, moderate; +++, severe. NS, no sample.
b
*, one of three animals had mild enteritis, and virus was detected in rectal swabs at 3 dpi.