Fig. 7.

Binding of RSV-neutralizing molecules to different F glycoprotein conformations. A schematic of the RSV F glycoprotein in the prefusion, intermediate, and postfusion states is shown, along with a table indicating whether various RSV-neutralizing molecules are expected to bind the different states. The green cylinders represent heptad repeat B (HRB), the red ovals represent domains I and II and the portion of domain III that appears to be conformationally static (as described by Yin et al. [44]), and the blue ovals represent the portion of domain III that does refold to form heptad repeat A (blue cylinders). TMC353121 is a small molecule that inhibits fusion by disrupting formation of the postfusion six-helix bundle (35).