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. 2011 Aug;85(15):7563–7571. doi: 10.1128/JVI.00630-11

Fig. 1.

Fig. 1.

Receptor-mimetic constructs. (A) CCR5mim (green bar, previously described as pΔE51 [12]) and CD4mim (red circle, a natural amino acid form of the previously described CD4-mimetic peptide CD4M33 [23, 32]) are shown with their sequences to the right. At least four of the tyrosines of CCR5mim are modified by sulfate (SO4), as indicated. Red indicates residues of CCR5mim and CD4mim identical to CCR5 and CD4, respectively, and critical for gp120 association. The disulfide bonds of CD4mim are indicated by connecting lines. (B) DM1, a peptide composed of CD4mim and CCR5mim linked by a (GSGGG)2 linker, is represented. Fusions of these peptides with the Fc region of human IgG1 (CCR5mim-Ig, CD4mim-Ig, and DM1-Ig), as well as with domains 1 and 2 of CD4 (CD4-Ig), are also shown.