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ARQ/ARQ sheep brain homogenate used as substrate in PMCA. (A) PK-resistant PrPSc from 10−2 to 10−6 serial dilutions of the inoculum in the substrate, before (−) and after (+) one round of PMCA (in duplicate), as detected by WB. (B) After a longer exposure time for the same blot, it is possible to detect PK-resistant PrPSc up to 10−5 dilutions.
