Fig. 8.
Pathogenicity evaluation in chickens and mice. (A) Pathogenicity assay in SPF eggs and chickens. The MDT, ICPI, and IVPI were determined as described in Materials and Methods. (B) Weight changes of mice inoculated with recombinant and vector viruses. Groups of five mice were inoculated i.m. in the thigh muscle of a hind leg (I) or i.c. (II) with 108.3 EID50 (in 30 μl) of rL or rL-RVG and observed and weighed daily for 14 days. All mice survived for the duration of the experiment. Body weight changes for each group are shown as ratios of the body weight at day 0, which was set as 100.