Table.
Genes are Differentially Expressed in Periodontitis vs. Healthy Gingival Tissues from Adult and Aged Non-human Primates
| Adult |
Aged |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Probe # | Healthy | Periodontitis | Fold-change | P Value | Healthy | Periodontitis | Fold-change | P Value | |
| Pro-apoptosis | |||||||||
| BCL2L10 | MmugDNA.5988.1.S1_at | 159.9 | 236.4 | 1.5 | 0.031 | 175.2 | 255.1 | 1.5 | 0.123 |
| CAPN1 | MmugDNA.2588.1.S1_at | 2694.5 | 3556.5 | 1.3 | 0.038 | 3286.7 | 3488.1 | 1.1 | 0.757 |
| NOD1 | Mmu.9460.1.S1_s_at | 3240.7 | 2909.8 | 0.9 | 0.029 | 3031.3 | 2808.9 | 0.9 | 0.226 |
| PPP3CB | Mmu.9989.1.S1_s_at | 773.5 | 718.3 | 0.9 | 0.004 | 821.2 | 689.9 | 0.8 | 0.257 |
| CHP | MmugDNA.2197.1.S1_at | 315.1 | 224.8 | 0.7 | 0.017 | 276.8 | 318.4 | 1.2 | 0.477 |
| TNFRS11B | MmugDNA.5860.1.S1_at | 244.3 | 152.3 | 0.6 | 0.044 | 182.3 | 188.8 | 1.0 | 0.904 |
| APAF1 | MmugDNA.37857.1.S1_at | 42.6 | 30.8 | 0.7 | 0.617 | 19.6 | 45.6 | 2.3 | 0.006 |
| CSF2RB | MmugDNA.35543.1.S1_at | 3102.3 | 4439.2 | 1.4 | 0.276 | 2848 | 4555.4 | 1.6 | 0.016 |
| CASP3 | MmugDNA.6342.1.S1_at | 1008.3 | 874.5 | 0.9 | 0.575 | 731.2 | 1132.6 | 1.5 | 0.018 |
| DAPK1 | MmugDNA.31762.1.S1_at | 139.1 | 170.3 | 1.2 | 0.151 | 140.7 | 184.3 | 1.3 | 0.009 |
| TRAF 3 | MmugDNA.10177.1.S1_at | 381.0 | 329.8 | 0.9 | 0.405 | 293.0 | 388.2 | 1.3 | 0.005 |
| CASP1 | MmugDNA.31375.1.S1_s_at | 563.7 | 713.4 | 1.3 | 0.172 | 820.8 | 600.3 | 0.7 | 0.002 |
| CASP4 | MmugDNA.24199.1.S1_at | 2352.5 | 2854.4 | 1.2 | 0.396 | 3140.9 | 1997.9 | 0.6 | 0.042 |
| CD40 (TNFRSF5) | MmugDNA.20032.1.S1_at | 27.5 | 24.4 | 0.9 | 0.849 | 14.2 | 5.8 | 0.4 | 0.040 |
| Anti-apoptosis | |||||||||
| IGF1R | MmugDNA.12698.1.S1_at | 18.1 | 46.8 | 2.6 | 0.047 | 23.3 | 10.8 | 0.5 | 0.265 |
| PRKX | MmugDNA.3488.1.S1_at | 25.7 | 41.7 | 1.6 | 0.048 | 41.2 | 42.9 | 1.0 | 0.919 |
| NFKB1 | MmugDNA.25322.1.S1_at | 652.0 | 799.1 | 1.2 | 0.017 | 760.0 | 737.2 | 1.0 | 0.688 |
| PRKAR1A | MmuSTS.3698.1.S1_at | 12146.3 | 10773.6 | 0.9 | 0.036 | 11708.5 | 10383.9 | 0.9 | 0.213 |
| NOL3 | MmugDNA.27369.1.S1_at | 401.6 | 301.6 | 0.8 | 0.044 | 339.1 | 310.4 | 0.9 | 0.481 |
| BNIP2 (II) | MmugDNA.2960.1.S1_at | 43.0 | 18.1 | 0.4 | 0.047 | 14.0 | 27.1 | 1.9 | 0.293 |
| NTRK1 | MmugDNA.14382.1.S1_at | 23.9 | 43.3 | 1.8 | 0.077 | 17.2 | 62.3 | 3.6 | 0.027 |
| BNIP3L | MmugDNA.32220.1.S1_at | 36.7 | 50.0 | 1.4 | 0.339 | 40.1 | 77.3 | 1.9 | 0.026 |
| PRKACA | MmuSTS.3696.1.S1_at | 590.6 | 631.1 | 1.1 | 0.617 | 567.4 | 693.2 | 1.2 | 0.014 |
| RELA | MmuSTS.3377.1.S1_at | 1360.6 | 1312.5 | 1.0 | 0.694 | 1295.9 | 1434.4 | 1.1 | 0.032 |
| BNIP2 (I) | MmugDNA.31249.1.S1_at | 2217.0 | 2374.6 | 1.1 | 0.537 | 2347.5 | 2031.5 | 0.9 | 0.022 |
| BCL2L2 | MmugDNA.17683.1.S1_at | 348.8 | 319.4 | 0.9 | 0.458 | 353.0 | 300.5 | 0.9 | 0.013 |
| CD2 (cytoplasmic tail) | MmugDNA.32305.1.S1_at | 323.6 | 405.6 | 1.3 | 0.213 | 479.8 | 372.7 | 0.8 | 0.025 |
| PIK3CA | MmuSTS.1135.1.S1_at | 1665.3 | 1696.2 | 1.0 | 0.899 | 1749.8 | 1395.0 | 0.8 | 0.021 |
The average expression and fold-change for 28 genes related to apoptotic pathways that showed significant differences (p ≤ 0.05) between healthy and periodontitis gingival tissue from either adult or aged animals is shown. Genes were divided as positive (pro-apoptosis) or negative (anti-apoptosis) regulators of programmed cell death. The corresponding probe number IDs for the listed genes were obtained from the database of the Affymetrix Web site with the NetAffx Query software (www.affymetrix.com).