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Multimodality imaging of mice with fracture putty implants. Human fibroblast cells transduced with AdBMP2 were injected into the right hind limb of NOD/SCID mice. Mice were injected with 68Ga-M2 and imaged at 18 h. NIR images (A,C) were acquired on day 4 post-implantation and follow-up CTs (B,D) were taken on day 11. Solid arrows indicate site of new bone formation and agent accumulation. Dashed arrows designate control (empty cassette) injection sites in the contralateral limb.
