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. Author manuscript; available in PMC: 2011 Aug 1.

Published in final edited form as: Open Nutraceuticals J. 2011 Jan 1;3:100–111. doi: 10.2174/1876396001003010100

Fig. 9 — (9A). Hyzaar induces CHAT in diastolic (D) blood pressure (BP) of one patient when given at some but not at other circadian stages. This figure is pertinent to large numbers of people worldwide, who are currently treated for high BP. They must realize that a popular drug, if prescribed without personalized surveillance, can harm by inducing a Vascular Variability Disorder (VVD), such as a circadian overswing or CHAT (Circadian Hyper-Amplitude-Tension). A change in the time when the drug is taken can make the same dose of the same drug in the same person beneficial rather than harmful or vice versa [21]. The drug can eliminate CHAT, a risk of stroke and other morbid events greater than a high BP, or induce it, depending on timing. Hyzaar was taken at one of 6 treatment times during waking, the schedule being changed monthly, with monitoring around the clock at 30-min intervals during the last week of each month. Differential effects on the MESOR (M) (top) and circadian amplitude (A) (bottom) of DBP. Differential effects of the same drug in the same dose in the same person occurring, all else being equal, as a function of the timing of the drug’s use along the scale of 24 hours, yet without an account for any infradian dynamics that should prompt repeated administrations at the time found optimal only or in the course of a second cycle of variations in treatment times. Continued surveillance is best best implemented to avoid harm. Study by Dr. Yoshihiko Watanabe. © Halberg. (9B). Hyzaar exacerbates a preexisting CHAT in the systolic (S) blood pressure (BP) of Figure 9a’s patient when given in the morning and eliminates this pre-existing VVD when given in the evening [21]. Study by Dr. Yoshihiko Watanabe. © Halberg. (9C). Without surveillance, we leave it up to chance and ignore whether we do harm at one time, shown in black (middle), while we can be beneficial at another time (right). © Halberg. (9D). If timing is not tested, insofar as vascular variability disorders (VVDs) are concerned (see Figs. 9A–C), the blind (care providers) lead the blind (care recipients) (bottom), showing the status quo. The painting at the bottom by Pieter Brueghel, “The Parable of the Blind Leading the Blind”, is reproduced by kind permission of the Fototeca della Soprintendenza of the BAS PSAE and of the Polo Museale of the City of Naples, in order to emphasize that CHAT is silent to both the caregiver acting on the basis of a conventionally interpreted (chronobiologically uninterpreted) 24-hour blood pressure as well as to the majority of providers treating on the basis of single measurements in their office. © Halberg.

Fig. 9 — (9A). Hyzaar induces CHAT in diastolic (D) blood pressure (BP) of one patient when given at some but not at other circadian stages. This figure is pertinent to large numbers of people worldwide, who are currently treated for high BP. They must realize that a popular drug, if prescribed without personalized surveillance, can harm by inducing a Vascular Variability Disorder (VVD), such as a circadian overswing or CHAT (Circadian Hyper-Amplitude-Tension). A change in the time when the drug is taken can make the same dose of the same drug in the same person beneficial rather than harmful or vice versa [21]. The drug can eliminate CHAT, a risk of stroke and other morbid events greater than a high BP, or induce it, depending on timing. Hyzaar was taken at one of 6 treatment times during waking, the schedule being changed monthly, with monitoring around the clock at 30-min intervals during the last week of each month. Differential effects on the MESOR (M) (top) and circadian amplitude (A) (bottom) of DBP. Differential effects of the same drug in the same dose in the same person occurring, all else being equal, as a function of the timing of the drug’s use along the scale of 24 hours, yet without an account for any infradian dynamics that should prompt repeated administrations at the time found optimal only or in the course of a second cycle of variations in treatment times. Continued surveillance is best best implemented to avoid harm. Study by Dr. Yoshihiko Watanabe. © Halberg. (9B). Hyzaar exacerbates a preexisting CHAT in the systolic (S) blood pressure (BP) of Figure 9a’s patient when given in the morning and eliminates this pre-existing VVD when given in the evening [21]. Study by Dr. Yoshihiko Watanabe. © Halberg. (9C). Without surveillance, we leave it up to chance and ignore whether we do harm at one time, shown in black (middle), while we can be beneficial at another time (right). © Halberg. (9D). If timing is not tested, insofar as vascular variability disorders (VVDs) are concerned (see Figs. 9A–C), the blind (care providers) lead the blind (care recipients) (bottom), showing the status quo. The painting at the bottom by Pieter Brueghel, “The Parable of the Blind Leading the Blind”, is reproduced by kind permission of the Fototeca della Soprintendenza of the BAS PSAE and of the Polo Museale of the City of Naples, in order to emphasize that CHAT is silent to both the caregiver acting on the basis of a conventionally interpreted (chronobiologically uninterpreted) 24-hour blood pressure as well as to the majority of providers treating on the basis of single measurements in their office. © Halberg.