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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Exp Dermatol. 2008 Mar 13;17(9):752–760. doi: 10.1111/j.1600-0625.2008.00716.x

Figure 5.

Figure 5

Hydrocortisone (HC) substantially inhibits adenosine-5′-triphosphate (ATP)γS-induced CXCL8 and CXCL1 production by human microvascular endothelial cell line-1 (HMEC-1) while penicillin (PCN) has only a small inhibitory effect on CXCL1 and CXCL8 release. HMEC-1 cell cultures were treated with tetracycline (TCN), HC or PCN and then stimulated with ATPγS (100 μm) or left unstimulated. Supernatants were collected 24 h later and analysed for CXCL8 (a) and CXCL1 (b) content. (a) CXCL8: P = 0.006 for 10 μg/ml of TCN, P < 0.0001 for 100 μg/ml of TCN, P < 0.001 for 10 μg/ml of HC, P < 0.0001 for 100 μg/ml of HC, P = 0.09 for 10 μg/ml of PCN and P = 0.020 for 100 μg/ml of PCN. (b) CXCL1: P = 0.005 for 10 μg/ml of TCN, P < 0.0001 for 100 μg/ml of TCN, P = 0.58 for 10 μg/ml of HC, P < 0.0001 for 100 μg/ml of HC, P = 0.004 for 10 μg/ml of PCN and P = 0.012 for 100 μg/ml of PCN.