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. Author manuscript; available in PMC: 2012 Aug 3.
Published in final edited form as: J Am Chem Soc. 2011 Jul 12;133(30):11482–11484. doi: 10.1021/ja2048072

Table 1.

Evaluation of different fluorination reagentsa.

graphic file with name nihms311322t1.jpg
Fluorinating reagent: MeCN dioxane toluene
graphic file with name nihms311322t2.jpg <1% 88% 82%
graphic file with name nihms311322t3.jpg graphic file with name nihms311322t4.jpg graphic file with name nihms311322t5.jpg graphic file with name nihms311322t6.jpg graphic file with name nihms311322t7.jpg
<1%b <1%b <1%b <1%b <1%b
a)

Yields were determined by 19F NMR with internal standard.

b)

The commercially available deoxyfluorination reagents afforded no detectable 4-fluoroanisole in MeCN, 1,4-dioxane, or toluene.