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Ligand sensitivity profiles of TSHR variants: TSHR (A), C600R (B), L467P (C), C41S (D), and L252P (E). Transfected HEK-EM293 cells were stimulated with DMSO, 10 mU/mL TSH, or 10 μM C2 for 1 hour in the presence of 500 μM 3-isobutyl-1-methylxanthine (IBMX). After incubation with agonists, intracellular cyclic adenosine monophosphate (cAMP) was measured and three distinct profiles arose. Bars represent mean ± SEM. **p ≤ 0.005.
