FIG. 4.

C2 causes persistent cAMP signaling and desensitization of TSHR (A) and C600R (B). Cells were pretreated with DMSO, TSH, or C2 for 20 hours and then incubated without ligands for 24 hours. Bars represent mean ± SEM. *p ≤ 0.05; **p ≤ 0.005.