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Relative levels of p53, MDMX and MDM2 after treatment with Nutlin-3. Protein levels are normalized by their steady levels before the treatment:104 (p53), 5.6 × 104 (MDM2) and 8.7 × 104 (MDMX) molecules per cell (Wang et al., 2007). In simulations, effect of Nutlin-3 is modeled by decreasing c24, c29, c31, c33, c35, c41 and c42 100 times. Simulation results are compared with experimental results (Wang et al., 2007).
