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. Author manuscript; available in PMC: 2012 Jun 8.
Published in final edited form as: Cell Metab. 2011 Jun 8;13(6):739–748. doi: 10.1016/j.cmet.2011.05.002

Figure 1. Increased adiposity in desnutrin-ASKO mice.

Figure 1

A) Generation of adipose-specific desnutrin knockout mice. B) Western blotting of lysates (40μg) from WAT, BAT, heart and liver using a desnutrin antibody (upper) and RT-qPCR for desnutrin expression in the macrophage and BAT (lower). C) Male mice on a HFD at 16-wks of age. D) Gonadal, renal and BAT fat depots (upper, middle and lower). E) Gonadal (Gon), Inguinal (Ing), renal (Ren) and brown adipose tissue (BAT) fat pad weights and food intake (inset) (n=7). F) liver, kidney, heart and lung weights (n=7). G) Hematoxylin and eosin-stained paraffin-embedded sections of gonadal (left) and BAT (right) and quantification of cell size. Scale bar (WAT)=20μm, scale bar (BAT)=40μm. Data are expressed as means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001