Table 2.
Linear mixed model ANCOVA F-test results [sensation seeking group (SS), dose (D) and group × dose interactions, with baseline measures, sex and alcohol intake serving as covariates] and level of significance for diazepam and d-amphetamine datasets
| Diazepam
|
d-Amphetamine
|
|||||
|---|---|---|---|---|---|---|
| SS | Dose | SS × D | SS | Dose | SS × D | |
| DSST | ||||||
| Trial rate | 3.41 | 1.36 | 13.60*** | 2.70 | 2.67 | 3.22* |
| Percent correct | 0.29 | 0.57 | 2.27 | 0.06 | 2.33 | 0.73 |
| Repeated acquisition | ||||||
| Learning | ||||||
| Correct rate | 1.60 | 0.54 | 0.26 | 1.18 | 0.16 | 3.07* |
| Incorrect rate | 1.23 | 2.92* | 0.16 | 1.00 | 0.82 | 1.56 |
| Index of curvature | 0.36 | 0.38 | 0.96 | 0.01 | 2.44 | 1.49 |
| Performance | ||||||
| Correct rate | 0.89 | 3.46* | 1.76 | 0.14 | 7.54*** | 0.36 |
| Incorrect rate | 0.57 | 2.76* | 3.53* | 2.68 | 1.63 | 0.27 |
| Cardiovascular | ||||||
| Rest | ||||||
| Heart rate | 0.71 | 0.77 | 2.13 | 0.33 | 2.07 | 0.09 |
| Systolic | 0.40 | 3.65* | 3.06* | 0.06 | 6.75*** | 1.77 |
| Diastolic | 0.29 | 1.64 | 3.27* | 0.15 | 2.95* | 3.88** |
| Task | ||||||
| Heart rate | 0.96 | 0.99 | 0.64 | 1.09 | 3.74* | 0.24 |
| Systolic | 0.98 | 3.31* | 1.03 | 0.53 | 6.98*** | 2.18 |
| Diastolic | 0.51 | 1.85 | 3.31* | 0.09 | 0.84 | 2.58 |
| ARCI | ||||||
| PCAG | 0.70 | 6.94*** | 1.86 | 0.00 | 2.21 | 0.42 |
| BG | 8.90** | 5.32*** | 4.29** | 10.91** | 3.98** | 2.69* |
| MBG | 8.54* | 1.20 | 0.85 | 11.42** | 1.60 | 2.30 |
| LSD | 0.23 | 2.75* | 0.19 | 0.07 | 0.13 | 1.20 |
| Amphetamine | 6.95* | 3.82** | 4.24** | 11.78** | 2.67* | 1.70 |
| POMS | ||||||
| Anxiety | 1.15 | 1.21 | 2.00 | 1.25 | 7.33*** | 1.06 |
| Depression | 0.27 | 0.59 | 4.58** | 0.25 | 0.16 | 2.26 |
| Anger | 0.89 | 0.40 | 1.20 | 0.48 | 1.47 | 2.82* |
| Vigor | 6.42* | 4.42** | 3.53* | 8.00* | 9.99*** | 2.88* |
| Fatigue | 0.16 | 1.14 | 2.88* | 0.52 | 1.02 | 1.91 |
| Confusion | 0.83 | 1.40 | 4.69** | 1.24 | 1.09 | 0.35 |
| Friendly | 6.23* | 0.15 | 1.73 | 9.26** | 1.31 | 0.09 |
| Elation | 8.85** | 1.16 | 0.37 | 15.19** | 4.71** | 0.74 |
| Arousal | 1.48 | 6.25*** | 0.62 | 1.64 | 12.66*** | 1.99 |
| Total positive | 5.76* | 5.48*** | 4.07** | 9.81** | 8.09*** | 4.29** |
| VAS | ||||||
| Stimulated | 5.51* | 3.25* | 1.96 | 6.26* | 2.07 | 1.33 |
| Stressed | 0.15 | 1.43 | 3.14* | 0.19 | 2.27 | 1.30 |
| Sedated | 0.00 | 10.69*** | 1.31 | 0.00 | 0.64 | 0.05 |
| Hungry | 0.03 | 2.10 | 1.85 | 0.01 | 2.19 | 2.40 |
| Anxious | 0.02 | 2.16 | 1.09 | 0.15 | 0.33 | 0.51 |
| Light-headed | 1.13 | 4.33** | 2.17 | 0.39 | 2.05 | 2.93* |
| Thirsty | 0.56 | 0.93 | 3.11* | 0.55 | 1.56 | 8.93*** |
| Sleepy | 0.89 | 4.78** | 2.78* | 1.81 | 0.04 | 1.13 |
| Sick-to-stomach | 0.03 | 1.68 | 0.37 | 0.34 | 1.51 | 0.82 |
| Down | 0.99 | 4.86** | 0.47 | 0.45 | 3.32* | 0.72 |
| High | 1.15 | 1.27 | 0.42 | 3.75 | 1.82 | 0.50 |
| Feel drug | 2.84 | 15.46*** | 1.51 | 1.16 | 3.97** | 0.34 |
| Like drug | 4.11 | 0.17 | 0.57 | 6.38* | 1.49 | 1.56 |
ANCOVA, analysis of covariance; ARCI, Addiction Research Center Inventory; BG, Benzedrine-Group; DSST, Digit Symbol Substitution Task; LSD, Lysergic Acid Diethylamide; MBG, Morphine-Benzedrine Group; PCAG, Pentobarbital, Chlorpromazine, Alcohol Group; POMS, Profile of Mood States; VAS, Visual Analog Scale.
*
P < 0.05.
**
P < 0.01.
***
P < 0.001.