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Adapted from [34]. The tree shows the duplication of G6PD, leading to the presence of H6PD in an ancestor to metazoa and choanoflagellates (green star), and the subsequent fusion of H6PD to 6PGL in an ancestor of only Metazoa (red star). Protostomes subsequently lost their copy of H6PD (blue star) and Aves lost their copy of G6PD (not shown; see Figure 2).
