Figure 3. STAT3 Inhibits Regulatory T Cell Conversion in Colitis.

(A) The proportions and (B) absolute numbers (mean ± SEM) of Foxp3-expressing CD4⁺ T cells in the tissues of control (Stat3^fl/fl) or Stat3^−/− (Cd4 Cre; Stat3^fl/fl) mice are shown. Data are representative of three independent experiments.

(C and D) Colitis was induced in Rag2^−/− mice as described in Figure 1. Intracellular Foxp3 expression in the tissues is shown in (C), and in (D), proportions of Foxp3⁺ cells among CD4⁺ T cells represent data pooled from four independent experiments. See also Figure S2. ^*p < 0.05, ^**p < 0.01.