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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Immunity. 2010 May 20;32(5):605–615. doi: 10.1016/j.immuni.2010.05.003

Figure 6. STAT3 Has a Nonredundant Role in T Cell Survival and Proliferation.

Figure 6

(A and B) Control (Stat3fl/fl) or Stat3−/− (Cd4 Cre; Stat3fl/fl) naive T cells were transferred into Rag2−/− mice and cell division was assessed by CFSE dilution.

(B) The absolute numbers of CD4+ TCR-β+ cells in the spleen at day 5 and 7 are shown; data are representative of two independent experiments.

(C) Control and Stat3−/− CD4+ T cells were cultured for 3 days in medium or with the indicated cytokines and the proportion of apoptotic (Annexin-V/PI positive) cells was determined by flow cytometry. Means (±SEM) of apoptotic cells from three independent experiments are shown. See also Figure S5. *p < 0.05; **p < 0.005.