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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Immunity. 2010 May 20;32(5):605–615. doi: 10.1016/j.immuni.2010.05.003

Figure 7. STAT3 Directly Regulates Genes Involved in CD4+ T Cell Survival and Proliferation.

Figure 7

(A) STAT3 binding (second panel) and H3K4me3 modifications (lower panels) were determined by ChIP-Seq. Conserved noncoding sequences are shown in the top panel. Arrows indicate directionality of transcription. See also Table S1.

(B and C) Control or Stat3−/− T cells were cultured for 3 days with the indicated cytokines and the effect of STAT3 on gene expression was assessed by (B) microarray and (C) quantitative PCR (mean ± SEM; n = 2 samples).