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. Author manuscript; available in PMC: 2012 Aug 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2011 Jun 6;255(1):76–85. doi: 10.1016/j.taap.2011.05.019

Fig. 3. Effects of OAT and 3′-MeDAB on hepatic Cyp2b10, Cyp2c29, Cyp3a11, Ugt1a1, Mrp4, Mrp2 and c-Myc, mRNA expression in wild-type (left panels) vs. CAR knock-out (right panels) mice.

Fig. 3

Mice were injected i.p. with a single dose of OAT (225 mg/kg) or 3′-MeDAB (225 mg/kg) and sacrificed 3 hours later. TCPOBOP (TC, 3 mg/kg) was used as a positive control in WT mice and as a negative control in CAR KO mice. Corn oil (control) was used as a solvent. Gene expression changes were measured by Real-time Q-PCR and standardized for GAPDH mRNA levels. White bars, control; straight striped bars, OAT; oblique striped bars, 3’MeDAB; black bars, TC (TCPOBOP). Bars, mean values from three animals per group, ± SD. Statistical analysis was performed by a Student’s t-test (treatment vs. control). Significant differences are indicated with asterisks (*p<0.05, **p<0.01, ***p<0.001).