Plasma proteins that increased in tumor-bearing mice fell into major functional categories. (A) acute phase response proteins, mainly liver-derived, (B) proteins from tumor infiltrating immune cells (macrophages and neutrophils), and (C) proteins involved in cell movement and tumor microenvironment, e.g. cytoskeletal, extracellular matrix, and tumor stroma proteins. Red indicates case/control ratios >1.5 (p<0.05), black indicates no change between case and control plasma, and white indicates the proteins were not measured. For the breast cancer cell lines, red indicates the protein was identified by proteomic profiling and white indicates the protein was not identified. Unless otherwise indicated, levels were measured by LC-MS. *measured by Luminex/Rules Based Medicine. **measured by both LC-MS and Luminex/Rules Based Medicine.