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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Cancer Res. 2011 Jun 8;71(15):5090–5100. doi: 10.1158/0008-5472.CAN-11-0568

Figure 5. HER2/neu mammary tumor microenvironment schematic.

Figure 5

In addition to the tumor cells, Her2/neu tumors contain cancer associated macrophages (F4/80), cancer associated fibroblasts (α-smooth muscle actin (aSMA)), lymphocytes (CD3), blood vessels (not shown), and extensive collagen deposition (trichrome). Also shown are IHC results of HER2/neu tumors for Timp1 and Vasp which were elevated in plasma from tumor-bearing mice. Additional proteins elevated in plasma from tumor-bearing mice are listed according to functional categories (boxes).