Plasma levels of (A) Insulin-like growth factor binding protein 5 (Igfbp5), (B) Lipocalin-2 (Lcn2), (C) Metallopeptidase inhibitor-1 (Timp1), and (D) C-C motif chemokine 8 (Ccl8) as determined by ELISA in a set of mouse plasmas independent of those used for LC-MS/MS experiments. For each time point n=6 controls and n=6 cases. Statistical significance was determined by two-tailed Student's t-test *p<0.05, **p<0.01, and ***p<0.0001.