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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Mol Pharm. 2011 Jul 8;8(4):1390–1400. doi: 10.1021/mp200219e

Figure 7.

Figure 7

Average contrast-to-noise ratios (CNRs) and fold change in CNRs in tumor xenografts after subcutaneous injection of Gd-DO3A or ProGlo. A, Subcutaneous injection of Gd-DO3A demonstrated no significant enhancement in CNR of PR(+) or PR(-) tumors over time. B, Subcutaneous injection of ProGlo showed specific CNR enhancement in the PR(+) tumor over the PR(-) tumor at 6 hours post-injection (asterisk, Student's t-test, p < 0.05). Error bars represent ± standard deviation of the mean. C, Representative images of xenografted mice injected subcutaneously with Gd-DO3A (top panels) or ProGlo (bottom panels). White scale bars represent 5 mm.