Table 1.
Influence of transmural pressure on parameters of active lymph pump in segments of rat mesenteric lymphatic vessels (control and after administration of L-NAME) in 9-mo and 24-mo old animals.
| Transmural Pressure (cm H2O) |
Treatment | LTI (%) |
AMP (%) |
FREQ (min−1) |
FPF (min−1) |
|---|---|---|---|---|---|
| 1 | 9 mo Control | 7.7 ± 1.5 | 24 ± 3 | 6.9 ± 1.6 | 3.3 ± 0.6 |
| 9 mo L-NAME 100 µM | 19.8 ± 3.3 | 22 ± 4 | 13.7 ± 4.1 | 5.0 ± 0.7 | |
| 24 mo Control | 6.9 ± 0.9 | 11 ± 3 | 1.3 ± 0.6 | 0.5 ± 0.2 | |
| 24 mo L-NAME 100 µM | 8.8 ± 2.0 | 22 ± 5 | 3.0 ± 0.8 | 1.7 ± 0.5 | |
| 3 | 9 mo Control | 6.5 ± 1.1 | 27 ± 2 | 12.1 ± 2.1 | 5.4 ± 0.7 |
| 9 mo L-NAME 100 µM | 12.4 ± 3.8 | 28 ± 4 | 19.0 ± 4.1 | 8.8 ± 0.7 | |
| 24 mo Control | 6.3 ± 0.5 | 18 ± 2 | 4.2 ± 1.1 | 1.6 ± 0.4 | |
| 24 mo L-NAME 100 µM | 5.5 ± 0.7 | 24 ± 4 | 6.5 ± 1.3 | 2.9 ± 0.7 | |
| 5 | 9 mo Control | 5.6 ± 1.0 | 21 ± 2 | 12.5 ± 2.0 | 4.6 ± 0.7 |
| 9 mo L-NAME 100 µM | 10.3 ± 3.2 | 24 ± 3 | 19.7 ± 4.5 | 8.0 ± 0.8 | |
| 24 mo Control | 5.5 ± 0.4 | 15 ± 2 | 5.5 ± 1.6 | 1.7 ± 0.3 | |
| 24 mo L-NAME 100 µM | 4.8 ± 0.7 | 17 ± 3 | 6.6 ± 1.3 | 2.1 ± 0.4 | |
| 7 | 9 mo Control | 5.3 ± 1.7 | 20 ± 2 | 13.5 ± 3.2 | 4.8 ± 1.2 |
| 9 mo L-NAME 100 µM | 9.7 ± 3.1 | 19 ± 3 | 20.3 ± 4.5 | 6.8 ± 0.8 | |
| 24 mo Control | 5.3 ± 0.8 | 11 ± 2 | 6.4 ± 1.3 | 1.5 ± 0.3 | |
| 24 mo L-NAME 100 µM | 5.0 ± 0.9 | 12 ± 2 | 8.8 ± 2.0 | 2.2 ± 0.6 |
Values are means ± SE; n=17 (9-mo), n=17 (24-mo); LTI, lymphatic tone index; AMP, contraction amplitude; FREQ, contraction frequency; FPF, fractional pump flow.