Table 2.
Influence of imposed flow gradients on parameters of active lymph pump in segments of rat mesenteric lymphatic vessels (control and after administration of L-NAME) in 9-mo and 24-mo old animals.
| Imposed Flow Gradient (cm H2O) |
Treatment | LTI (%) |
AMP (%) |
FREQ (min−1) |
FPF (min−1) |
|---|---|---|---|---|---|
| 0 | 9 mo Control | 6.7 ± 1.1 | 23 ± 2 | 12.3 ± 2.1 | 4.7 ± 0.7 |
| 9 mo L-NAME 100 µM | 11.0 ± 3.2 | 21 ± 4 | 20.0 ± 4.4 | 7.4 ± 1.3 | |
| 24 mo Control | 5.8 ± 0.4 | 15 ± 2 | 5.9 ± 1.5 | 1.7 ± 0.4 | |
| 24 mo L-NAME 100 µM | 5.4 ± 1.0 | 18 ± 5 | 5.8 ± 1.6 | 2.1 ± 0.6 | |
| 1 | 9 mo Control | 5.6 ± 0.9 | 22 ± 2 | 10.7 ± 1.9 | 4.0 ± 0.7 |
| 9 mo L-NAME 100 µM | 9.7 ± 3.1 | 22 ± 4 | 18.5 ± 4.3 | 6.7 ± 1.1 | |
| 24 mo Control | 4.8 ± 0.4 | 13 ± 2 | 5.5 ± 1.5 | 1.3 ± 0.4 | |
| 24 mo L-NAME 100 µM | 4.8 ± 0.8 | 16 ± 4 | 6.1 ± 1.7 | 1.9 ± 0.5 | |
| 3 | 9 mo Control | 5.5 ± 1.6 | 21 ± 2 | 10.9 ± 1.7 | 3.5 ± 1.4 |
| 9 mo L-NAME 100 µM | 9.4 ± 3.0 | 19 ± 3 | 18.6 ± 4.4 | 6.3 ± 1.2 | |
| 24 mo Control | 5.3 ± 0.7 | 13 ± 4 | 3.8 ± 1.6 | 0.9 ± 0.4 | |
| 24 mo L-NAME 100 µM | 4.5 ± 0.8 | 14 ± 4 | 6.5 ± 2.1 | 1.7 ± 0.6 | |
| 5 | 9 mo Control | 5.4 ± 0.8 | 21 ± 3 | 9.2 ± 1.8 | 3.3 ± 0.8 |
| 9 mo L-NAME 100 µM | 9.0 ± 2.7 | 18 ± 3 | 17.3 ± 4.3 | 5.6 ± 1.2 | |
| 24 mo Control | 4.7 ± 0.5 | 9 ± 3 | 3.8 ± 1.4 | 1.2 ± 0.5 | |
| 24 mo L-NAME 100 µM | 4.4 ± 1.0 | 14 ± 4 | 5.7 ± 2.2 | 1.4 ± 0.5 |
Values are means ± SE; n=14 (9-mo), n=14 (24-mo); LTI, lymphatic tone index; AMP, contraction amplitude; FREQ, contraction frequency; FPF, fractional pump flow.